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Prx1 This is a dimer of two typical 2-Cys subunits. The interface between them is known as the B-interface. The subunits interact in a head-to-head manner (⇒⇐), primarily through the β-strands. Together they form a single, extended β-sheet. Cho, K., Lee, J.-H., Khan, T., Park, Y., Cho,
A., Chang, T.-S., and Kim, K. Crystal Structure of Dimeric Human
Peroxiredoxin-1 C83S Mutant. Bulletin of the Korean Chemical
Society (2015) 36: 1543-1545. 4xcs (PDB) |
Prx5
from Plasmodium falciparum
This is a dimer of two atypical 2-Cys subunits. This interface is known as the A-interface. The subunits are aligned side-to-side (⇑⇓). Staudacher, V., Djuika, C. F., Koduka, J., Schlossarek, S., Kopp, J., Büchler, M., Lanzer, M., and Deponte, M. Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins. Free Radical Biology and Medicine (2015) 85, 228–236. (PubMed) 4d73 (PDB) |